atorvastatin and grapefruit juice side effects

If the answer is yes, ask whether you need to eliminate that food from your diet. Always ask your doctor or pharmacist when you get a new prescription if it interacts with any foods or other medicines. For example, numerous citrus-flavored soft drinks contain grapefruit juice or grapefruit extract. The list of medications that can interact with grapefruit includes commonly prescribed medications that:Īnother potential problem is that some foods and drinks may contain grapefruit but don't say so in the name or on the ingredients list.

When a single 40 mg dose of atorvastatin was coadministered with 240 mL of grapefruit juice, atorvastatin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 16 and 37, respectively. On the other hand, a medication that stays in the body too long may build up to potentially dangerous levels. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. A medication that's broken down too quickly won't have time to work. As a result, the medication may stay in your body for too short or too long a time. Problems arise because chemicals in the fruit can interfere with the enzymes that break down (metabolize) the medication in your digestive system. Atorvastatin interacts with grapefruit juice if you. Alternatively, you can ask your doctor if there's a comparable medication you can take that doesn't interact with grapefruit. Grapefruit juice increases the level of simvastatin in your blood and makes side effects more likely. Simply taking your medication and grapefruit product at different times doesn't stop the interaction.

You may need to eliminate grapefruit products from your diet.

Atorvastatin and grapefruit juice side effects